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Acute Toxicity and Cytogenotoxicity of Yangambin Isolated from Ocotea duckei Vattimo‑Gil

1, 2, 3, 1, 4, 4, 4, 1, 2

  1. 1Postgraduate Program in Morphotechnology - Federal University of Pernambuco, João Pessoa, PB, BRAZIL.
  2. 2Postgraduate Program in Morphotechnology - Federal University of Pernambuco; Department of Histology and Embryology-Federal University of Pernambuco, João Pessoa, PB, BRAZIL.
  3. 3Multiprofessional Residency Program in Health Surveillance - Recife Health Department, João Pessoa, PB, BRAZIL.
  4. 4Institute of Drugs and Medicines Research - Federal University of Paraíba, João Pessoa, PB, BRAZIL.

CORRESPONDENCE

Maria Isabel de Assis Lima Castro

Postgraduate Program in Morphotechnology - Federal University of Pernambuco, João Pessoa, PB, BRAZIL.

isabellima878@gmail.com

Received: 04-08-2020; Accepted: 18-09-2020.

Volume 12, Issue 4 · pp. 444-449 · 2021 · DOI: 10.4103/pr.pr_73_20

ABSTRACT

Background: Yangambin, a lignan isolated from Ocotea duckei leaves, has been reported to have antitumor, anxiolytic, hypotensive, and leishmanicidal activity, but there is little information on toxicity.Objective: The aim of this study was to investigate the acute toxicity of yangambin in mice, and cytotoxicity and genotoxicity through the Allium cepa assay.Materials and Methods: The yanganbin at a dose of 2000 mg/kg was orally administered once to mice to investigate acute toxicity, and meristem of the roots of Allium cepa was used to determine inhibition of root growth (root length) and mitotic index.Results: Yangambin did not cause hemolysis in sheep erythrocytes at concentrations of 12.5, 25, and 50 µg/mL, and did not show genotoxic changes in root meristem cells of Allium cepa at the same concentrations. In the acute toxicity study in Swiss mice at a dose of 2000 mg/kg, there were no apparent clinical signs or any behavioral changes and no deaths.Conclusion: Therefore, yangambin appears to a promising active compound for future pharmacological studies.

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    Castro, M. I. D. A. L., Lucena, M. G. S. D., Silva, C. V. N. S., Xavie, Y. K. D. S., Filho, J. M. B., Teles, M. M. R. S., Peixoto, L. R., Souza, I. A. D., & Silva, E. C. D. (2021). Acute Toxicity and Cytogenotoxicity of Yangambin Isolated from Ocotea duckei Vattimo‑Gil. Pharmacognosy Research, 12(4), 444-449. https://doi.org/10.4103/pr.pr_73_20

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    © 2021 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0