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Ulcerative Colitis Induced with Acetic Acid is Ameliorated by Antrocaryon micraster through Reduced Serum Levels of Tumor Necrosis Factor Alpha and Interleukin‑6 in Sprague Dawley Rats

1, 2, 2, 2, 3

  1. 1Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, GHANA; Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri, Kansas City, Missouri, USA.
  2. 2Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, GHANA.
  3. 3Department of Pathology, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, GHANA.

CORRESPONDENCE

Newman Osafo

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, GHANA.

nosafo.pharm@knust.edu.gh

Volume 12, Issue 1 · pp. 85-91 · 2020 · DOI: 10.4103/pr.pr_75_19

ABSTRACT

Background: Antrocaryon micraster possesses significant antioxidant and anti‑inflammatory activities. These properties are shared by medicinal plants that have demonstrated beneficial effects in the treatment of ulcerative colitis.Objectives: To assess the effect of the total ethanol stem bark of A. micraster extract (AME) on damage to the rat colon in acetic acid‑induced colitis.Materials and Methods: Rats were pretreated with sulphasalazine 500 mg/kg or AME 30, 100, and 300 mg/kg daily for 3 days after which colitis was induced in test animals with acetic acid (4% V/V). Rats were sacrificed 24 h later and blood samples were obtained for hematological and cytokine assays. Colons were dissected for assessment of macroscopic and microscopic damage.Results: AME treatment modified hematological parameters and reduced serum levels of tumor necrosis factor alpha and interleukin‑6. Macroscopic assessment showed that AME reduced mucosal erythema, edema, erosions, bleeding, and ulceration. Histology showed preserved mucosal architecture, reduced inflammatory cell infiltration, decreased mucosal thickening, preserved goblet cell numbers, and inhibition of mast cell proliferation and degranulation in the colons.Conclusion: Taken together, the total ethanol stem bark AME exerts ameliorative effects on damage to the rat colon in acetic acid‑induced colitis.

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    Essel, L. B., Obiri, D. D., Osafo, N., Antwi, A. O., & Duduyemi, M. B. (2020). Ulcerative Colitis Induced with Acetic Acid is Ameliorated by Antrocaryon micraster through Reduced Serum Levels of Tumor Necrosis Factor Alpha and Interleukin‑6 in Sprague Dawley Rats. Pharmacognosy Research, 12(1), 85-91. https://doi.org/10.4103/pr.pr_75_19

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    © 2020 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0