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Leaf Extract of Eugenia uniflora L. Prevents Episodic Memory Impairment Induced by Streptozotocin in Rats

1, 2, 3, 4, 4

  1. 1Graduate Program in Biotechnology; Biological Sciences, Positivo University, Professor Pedro Viriato Parigot de Souza Street, CEP , Curitiba, PR, BRAZIL.
  2. 2Biological Sciences, Positivo University, Professor Pedro Viriato Parigot de Souza Street, CEP , Curitiba, PR, BRAZIL.
  3. 3Graduate Program in Biotechnology, Positivo University, Professor Pedro Viriato Parigot de Souza Street, CEP 81280-330, Curitiba, PR, BRAZIL.
  4. 4Graduate Program in Biotechnology; Biological Sciences, Positivo University, Professor Pedro Viriato Parigot de Souza Street, CEP 81280-330, Curitiba, PR, BRAZIL.

CORRESPONDENCE

Ilton Santos da Silva

Graduate Program in Biotechnology; Biological Sciences, Positivo University, Professor Pedro Viriato Parigot de Souza Street, 5300, CEP 81280-330, Curitiba, PR, BRAZIL.

ilton.silva@up.edu.br

Volume 11, Issue 3 · pp. 329-332 · 2019 · DOI: 10.4103/pr.pr_37_19

ABSTRACT

Background: Eugenia uniflora is a plant found in several countries of South America and is traditionally used in folk medicine as an antimicrobial, anti‑inflammatory, and antihypertensive agent.Objective: This study aimed to investigate the neuroprotective effect of the ethanolic extract of E. uniflora leaves on memory impairment induced by streptozotocin (STZ) in rats.Materials and Methods: The ethanolic extract of E. uniflora leaves was used to treat Wistar rats which received intracerebroventricular (ICV)‑STZ. Animals were allocated to the control group (n = 10), i.e., ICV vehicle solution + ethanol 10%; STZ group (n = 10), i.e., ICV‑STZ + ethanol 10%; STZ + E. uniflora (300 mg/kg) group (n = 10), i.e., ICV‑STZ +300 mg/kg of leaf extract of E. uniflora; and STZ + E. uniflora (1000 mg/kg) group (n = 10), i.e., ICV‑STZ +1000 mg/kg of leaf extract of E. uniflora. The animals were submitted to the treatments 24 h after receiving ICV‑STZ. The treatments were performed on alternate days over a 30‑day period. After this period, the animals were tested in the elevated plus maze to assess learning and memory.Results: The STZ group presented a higher transfer latency (P 0.05) for both the doses.Conclusion: The leaf extract of E. uniflora showed a neuroprotective effect on memory impairment induced by STZ in rats.

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    Silva, I. S. D., Corbellini, J. R., Pfutzenreuter, G., Maranho, L. T., & Pincerati, M. R. (2019). Leaf Extract of Eugenia uniflora L. Prevents Episodic Memory Impairment Induced by Streptozotocin in Rats. Pharmacognosy Research, 11(3), 329-332. https://doi.org/10.4103/pr.pr_37_19

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    © 2019 Author(s)

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