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In silico Anti‑Preeclampsia Potential of Phytochemical Found in Ficus elastica

1, 2, 1, 3, 3, 4, 5, 6, 6

  1. 1Department of Public Health, Faculty of Medicine, University of Prima Indonesia, Medan, INDONESIA.
  2. 2Department of Biomedical Science, Faculty of Medicine, University of Prima Indonesia, Medan, INDONESIA.
  3. 3Department of Medical Science, Faculty of Medicine, University of Prima Indonesia, Medan, INDONESIA.
  4. 4Department of Midwifery, Faculty of Health Science and Pharmacy, Adiwangsa Jambi University, Jambi, INDONESIA.
  5. 5Medical Research Center, Faculty of Medicine, Maranatha Christian University, Bandung, INDONESIA.
  6. 6Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung, INDONESIA.

CORRESPONDENCE

Chrismis Novalinda Ginting

Department of Public Health, Faculty of Medicine, University of Prima Indonesia, Medan, INDONESIA.

chrismis@unprimdn.ac.id

Volume 11, Issue 3 · pp. 279-282 · 2019 · DOI: 10.4103/pr.pr_176_18

ABSTRACT

Context: Preeclampsia (PE) is a disorder found in pregnant women characterized by high blood pressure and high protein content in urine. Delivery of the baby and placenta is the most recommended treatment in PE, but treating its symptoms (hypertension) has also been recommended.Aims: This study is intended to assess the major compounds found in Ficus elastica leaf as anti‑PE using an in silico approach. Settings and Design: All in silico analysis was performed under default settings.Subjects and Methods: Antioxidant and anti‑inflammatory probability values of the five compounds in F. elastica leaf are predicted using quantitative structure–activity relationship. The possible binding mode of the compounds is predicted using molecular docking.Results: Based on the structural properties, compounds found in F. elastica leaf have a high probability activity as an antioxidant and anti‑inflammatory. The compounds found in F. elastica, especially morin, have the highest binding affinity toward beta‑adrenergic receptor 2 (ADRB2) with similar intermolecular interaction with its known inhibitor.Conclusions: The compounds found in F. elastica may be beneficial for treating PE through its possible antioxidant and anti‑inflammatory properties and inhibition of ADRB2. Key words: Ficus elastica, hypertension, molecular docking.

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    Ginting, C. N., Lister, I. N. E., Girsang, E., Putri, Y. E., Mutia, M. S., Purba, R., Widowati, W., Wibowo, S. H. B., & Rizal, R. (2019). In silico Anti‑Preeclampsia Potential of Phytochemical Found in Ficus elastica. Pharmacognosy Research, 11(3), 279-282. https://doi.org/10.4103/pr.pr_176_18

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    © 2019 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0