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Chemical constituents and bioactivities of Malabaila suaveolens

1, 2, 3, 1, 1

  1. 1Chemistry of Natural Compounds Department, National Research Centre, 12622 Dokki, Cairo, Egypt.
  2. 2Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr-el-Aini Street, 11562 Cairo, Egypt.
  3. 3Pharmaceutical and Medicinal Chemistry Department, National Research Centre, 12622 Dokki, Cairo, Egypt.

CORRESPONDENCE

Nassar Mahmoud I.

Chemistry of Natural Compounds Department, National Research Centre, 12622 Dokki, Cairo, Egypt.

mnassar_eg@yahoo.com

Received: 29-08-2009; Accepted: 25-09-2009.

Volume 1, Issue 6 · pp. 342-347 · 2009 · DOI:

ABSTRACT

Volatile oil components, fatty acids, β-amyrin, and sterols were identified in the n-hexane extract of Malabaila suaveolens Coss. fruits. Angelicin, 4,7,9-trimethyl psoralen, isopimpinellin and umbelliferone were isolated from the dichloromethane extract of the plant. 5-Hydroxy 7, 3`, 4`-trimethoxyflavone, apigenin and its 7-O-β-D-glucopyranoside were isolated from the ethyl acetate extract. From the methanol extract, a new flavonoid, apigenin 7-O-(6``-O-p-hydroxybenzoyl)-β-D-glucopyranoside (1), along with vicenin 2, acacetin 7-O-rutinoside, and 6-hydroxyapigenin 7-O-β-D-glucopyranoside were isolated. Toxicity study of n-hexane, dichloromethane, ethyl acetate extract and methanolic extracts of the plant proved that it is relatively nontoxic. The tested extracts showed significant analgesic and anti-inflammatory effects as compared with control groups and reference drugs. Also, the tested extracts showed significant antioxidant activity as compared with reference.

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    I., N. M., A., A. E., A., M. Y., A., A. E., & F., O. A. (2009). Chemical constituents and bioactivities of Malabaila suaveolens. Pharmacognosy Research, 1(6), 342-347.

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    © 2009 Author(s)

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